Boxelder bugs are not known to bite, but their piercing-sucking mouthparts can occasionally puncture skin, causing a slight irritation and producing a red spot similar to a mosquito bite. When crushed or handled roughly, boxelder bugs may leave a reddish orange stain from their fecal material that can result in discoloration of curtains, drapes, and clothing.
To prevent boxelder bugs from invading homes, repair holes in window and door screens, seal cracks and crevices with a good quality silicone or silicone-latex caulk and install door sweeps to all exterior entrances.
If boxelder bugs have already entered a home or building, no attempt should be made to kill them in wall voids because dead insect bodies can attract dermestid beetles. Rather, using a vacuum cleaner to remove them may provide temporary relief. The bag should be removed to prevent the bugs from escaping.