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The most effective way to get rid of ladybugs or prevent them from entering homes and buildings is to seal cracks around windows, doors, siding, and utility pipes, behind chimneys, and underneath the wood fascia and other openings. Use a good quality silicone or silicone-latex caulk. Damaged screens on doors and windows should be repaired or replaced.

If ladybugs have already entered a home or building, a vacuum cleaner can aid in their removal.